Tuesday, December 15, 2020

Tuesday, December 15, 2020 12:30 am by M. in ,    No comments
A recent scholar paper in a French journal:
Hypostases of Time in Wuthering Heights
Nicoleta-Mariana Iftimie
Les Cahiers Linguatek n°. 7-8 (2020): "Temps et language", pp 61-69

And another paper that has nothing to do with Emily Brontë's novel except for using it in the title of the article. 2020 is coming to an end and what can be more 2020ish than a bit of COVID19 literature:

Sadí Cossy Isasi, Juan Carlos Muiño
Archivos de Alergia e Inmunología Clínica, 51.2 (2020): 69-82

This review ranges from Physicist-Chemical to Clinic on COVID-19. The crystalline structure by X-ray diffraction (resolution of 2.45) of the 2019-nCoV protein S (RBD) attached to ACE2, revealed a four-strand braided anti-parallelal sheet (1, 2, 3, and 6). Two lobes ACE2 terminal N domain form the active site. The 2019-nCoV RBD binds to the small lobe of ACE2, with a concave surface more polar than that of SARS CoV1 and with much greater affinity (KD 14.7 nM ~ hormone-receptor). SARS-CoV-2 protein S has a cutting site for proprotein-convertase (PPC) in S1/S2 absent in SARS-CoV1 and bat coronavirus. RBD, the most immunogenic portion, is hidden and is only exposed if furina TMPRSS2 and lysosome catepsins activate SARS CoV-2. By clamp movement, RBDs would facilitate the dimerization of ACE2 and penetration. ACE2 hydrolyzes a single terminal C residue in contrast to ACE, which hydrolyzes two. The differences are in the sub-site S2' and the junction of the terminal C peptide. ACE2 is expressed in the heart, kidneys and testicle, in addition to lung and degrades angiotensin II to produce angiotensin 1-7, its antagonist. In CL-presence, ACE increases its activity, but ACE2 is inhibited, suggesting that treats that increase chloride concentration are rejected. Laser  ispersion revealed that a one-minute locution is issued with a minimum of 19800 droplets of which 198 are infecting and remain in the air indefinitely. In experimental studies of animal coronaviruses, Muiño et al. found secondary hemophagocytic lymphohisthiocytosis (sHLH) characterized include fever, cytopenias and hyperferritinemia. Azithromycin, a macrolide that inhibits the production and secretion of IL-1, IL-6, IL-8 and TNF-a, in bronchoalveolar wash (LBA) of PBD patients is explored.


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